Monitor. J. Clin. -, Sakaeda T, Kadoyama K, Yabuuchi H, Niijima S, Seki K, Shiraishi Y, et al. Tachycardia and dyspnea persisted despite treatment with hydration, antihistamines, corticosteroids, and an oxygen mask. Our present findings confirmed these factors and identified other risk factors, including advanced disease, serous histology, and the presence of malignant ascites. Gynecol. doi: 10.1007/s00520-011-1123-y, Gomez, R., Harter, P., Lck, H. J., Traut, A., Kommoss, S., Kandel, M., et al. Abe et al. Carboplatin induces DNA double strand breaks, which are repaired by BRCA recombination repair enzymes. Bethesda, MD 20894, Web Policies desensitization; drug allergy; monoclonal antibodies in cancer; platins; taxanes. Webcasts and presentations from ESMO 2017 can be accessed by ESMO members and event attendees. ESMO is a Swiss-registered not-for-profit organisation. Such reactions could potentially be reduced or prevented by slowing the infusion rate and using a desensitization protocol involving anti-allergy medications. Cardiopulmonary resuscitation and endotracheal intubation were performed, but the patient finally expired due to respiratory failure. An official website of the United States government. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. CA. Markman, M. (2007). 57, 163167. Skin Testing and Basophil Activation Testing Is Useful for Assessing Immediate Reactions to Polyethylene Glycol-Containing Vaccines. Disclaimer. doi: 10.1200/JCO.2009.25.7519, Schwartz, J. R., Bandera, C., Bradley, A., Brard, L., Legare, R., Granai, C. O., et al. Borrs Cuartero J, Farzanegan Miano R, Torres Gorriz MC, Germn Snchez A, Aznar RC, Raducan I, Castell Carrascosa JV, Sanchez Hernandez A, Enrique E. Front Allergy. Check the latest publications and updates here to make sure you dont miss anything. Epub 2017 Feb 24. The symptoms and signs of the 75 women with carboplatin-related hypersensitivity reactions are given in Table 4. However, 48 (78.7%) of these patients developed repeated hypersensitivity reactions, even after pre-treatment with intravenous antihistamines, H2 blocker, and corticosteroids prior to carboplatin re-administration. A total of 59 women experienced mild signs and symptoms (grades 1 and 2), including skin rash (69.3%), skin itching (64.0%), facial flushing (56.0%), dyspnea (41.3%), chest pain (25.3%), tachycardia (18.7%), paresthesias (16.0%), abdominal cramping (13.3%), and diaphoresis (12.0%). Tamiya, M., Kuhara, H., Hirashima, T., Kondo, Y., Santo, M., Morishita, N., et al. 2022 Oct 18;12:994155. doi: 10.3389/fonc.2022.994155. A prospective single-center study. Supportive. Cisplatinum rechallenge in relapsed ovarian cancer patients with platinum reinduction therapy and carboplatin hypersensitivity. doi: 10.1016/j.ygyno.2006.04.002, Ozols, R. F., Bundy, B. N., Greer, B. E., Fowler, J. M., Clarke-Pearson, D., Burger, R. A., et al. The .gov means its official. Bookshelf With a lower carboplatin infusion rate and pre-treatment with anti-allergy drugs, all of these patients were able to tolerate re-treatment with carboplatin, although 48 (78.7%) of these 61 patients developed hypersensitivity again despite the desensitization protocol. All funding for this site is provided directly by ESMO. Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions. 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Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Analysis and interpretation of data: Y-HT, Y-JT, H-CH, Y-YC, and W-FC. Symptoms and signs of hypersensitivity reactions amendable to desensitization. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. doi: 10.1016/j.ygyno.2006.10.047, Shah, A. C., Minturn, J. E., Li, Y., Belasco, J. Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase1 Study of Intravenous Fosnetupitant. Pegylated liposomal doxorubicin and carboplatin compared with paclitaxel and carboplatin for patients with platinum-sensitive ovarian cancer in late relapse. Tyler T, Schultz A, Venturini A, Giuliano C, Bernareggi A, Spezia R, Voisin D, Stella V. Clin Pharmacol Drug Dev. The rate of hypersensitivity to carboplatin did not differ by patient age, menopausal status, disease entity, receipt of optimal debulking, or the amount of ascites. (2010). Oncol. Model of in vitro mouse mast cells activation and desensitization. 'Allergy' is a hypersensitivity reaction (HSR) initiated by specic immunolo- gical mechanisms. 2022 Dec;11(12):1405-1418. doi: 10.1002/cpdd.1183. (2013). Report of three cases. | DOI: 10.1097/HS9.0000000000000695. Multivariate analysis was conducted using logistic regression to estimate the association between the potential risk factors and the occurrence of hypersensitivity. It would be worthwhile to evaluate the correlation between other HRD genes and carboplatin hypersensitivity. For more detailed information on the cookies we use, please check our Privacy Policy. government site. 2019 Sep;60(9):2295-2298. doi: 10.1080/10428194.2019.1576871. Oncol. In 74 of the 75 patients, the hypersensitivity reactions subsided within several minutes to several hours after onset, and the patients recovered without any sequelae. (Bruchim et al., 2014) demonstrated safe re-treatment with carboplatin using a desensitization protocol to reduce repeated hypersensitivity reactions, and Koshiba et al. Annals of Oncology (2021) 32 (suppl_5): S407-S446. Libra, M., Sorio, R., Buonadonna, A., Berretta, M., Stefanovski, P., Toffoli, G., et al. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. For salvage chemotherapy in the case of recurrent disease, we administered chemotherapeutic regimens including carboplatin with paclitaxel, gemcitabine, or liposomal doxorubicin. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Please enable it to take advantage of the complete set of features! The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Cancer statistics, 2016. 144, 7782. However, other studies have reported severe hypersensitivity reactions to cisplatin in patients with prior carboplatin hypersensitivity reactions (Zweizig et al., 1994; Dizon et al., 2002). doi: 10.1093/annonc/mdx225. Though the characteristics of carboplatin-related hypersensitivity reactions are widely reported, limited data are available regarding such reactions in different types of patients. The essential content of the guidelinesin condensed slide format in PDF or PowerPoint. doi: 10.1093/annonc/mdx216. Chan. For more detailed information on the cookies we use, please check our Privacy Policy. 15, 780784. Unable to load your collection due to an error, Unable to load your delegates due to an error. 4-step 4-h carboplatin desensitization protocol for patients with gynecological malignancies showing platinum hypersensitivity: a retrospective study. Careers. (33)]. EHA Endorsement of ESMO Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up for Myelodysplastic Syndromes. This was the largest series of gynecological malignancies investigated for carboplatin-related hypersensitivity reactions. 24, 342351. Ann Oncol. The https:// ensures that you are connecting to the Women are more affected by drug allergy and up to 27% of women with ovarian and breast cancer develop carboplatin allergy after multiple cycles of treatment. Gynecol. (Moon et al., 2013) BRCA1/2 mutation patients had early-onset carboplatin hypersensitivity at a lower cumulative exposure. 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Copyright 2017 Tai, Tai, Hsu, Lee, Chen, Chiang, Chen, Chen and Cheng. J. Gynecol. ESMO 2017 Congress Integrating science into oncology for a better patient outcome Start date 08 Sep 2017 End date 12 Sep 2017 Location Madrid, Spain In an era of deep understanding of the molecular biology underlying the development of cancer, it is crucial that researchers and clinicians exchange knowledge. J. Gynecol. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Published in 2020 - Ann Oncol (2020) Authors: M.E. WHIPPANY, N.J., Sept. 1, 2017 /PRNewswire/ -- Bayer will present the latest research from across its growing oncology portfolio at the European Society for Medical Oncology (ESMO) 2017 Congress . Van Tine BA, Govindarajan R, Attia S, Somaiah N, Barker SS, Shahir A, Barrett E, Lee P, Wacheck V, Ramage SC, Tap WD. . Critical revision: C-AC. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. Monitor. The incidence of severe carboplatin-related hypersensitivity reactions ranges from 2 to 6%, with the lowest incidence occurring in our study. In the present study, 61 patients with carboplatin-related hypersensitivity were rechallenged with carboplatin. Characteristics of the 735 women receiving carboplatin-based chemotherapy. 2012;97:217-33. doi: 10.1159/000335637. (2006). Only 2 women are Mongolians and the other 733 women are Asian Taiwanese. Zhi. A history of drug or food allergy, the presence of malignant ascites, and the cumulative carboplatin dose are three independent predictive factors of carboplatin hypersensitivity in this survey. 329 (152 CPI-treated v 177 CPI-nave, including 60 tx-nave) pts with RET fusion+ NSCLC were analyzed. Invest. However, prolonged carboplatin use is associated with an increased incidence of carboplatin-related hypersensitivity reactions (Markman et al., 1999; Wang et al., 2009). Cancer 109, 10721078. J. Gynecol. Here, we retrospectively evaluated carboplatin-related hypersensitivity reactions among patients with gynecological cancer (ovarian, fallopian tube, or primary peritoneal cancer) who received carboplatin-containing regimens at a single medical institute in Taiwan. 17 This dose reduction is due to the ability of both aprepitant and netupitant to inhibit the metabolism of dexamethasone leading to higher . (2010) described the use of cisplatin as an alternative to carboplatin. doi: 10.1200/JOP.18.00761. 105, 14721479. doi: 10.1007/s00280-009-1159-6, Iwamoto, T., Hirai, H., Yamaguchi, N., Kobayashi, N., Sugimoto, H., and Tabata, T. (2014). doi: 10.1200/JCO.1999.17.4.1141, Moon, D. H., Lee, J. M., Noonan, A. M., Annunziata, C. M., Minasian, L., Houston, N., et al. 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Nektaria M, Ekaterini S, Ioannis K, Leonidas M, Muhammad Wasif S. Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review. Desensitization treatment with cisplatin after carboplatin hypersensitivity reaction in gynecologic cancer. Carboplatin hypersensitivity: evaluation and successful desensitization protocol. Efficacy and Adverse Events of Carboplatin Desensitisation Therapy for Gynaecological Cancer: A Retrospective Study. A framework to rank genomic alterations as targets for cancer precision medicine.ESCAT scores for genomic alterations with actionable drug matches are now being gradually integrated into ESMO tumour-focused Clinical Practice Guidelines. In the late 1980s, more than a dozen phase I studies analyzed the efficacy of paclitaxel as a single agent. Rosell S, Blasco I, Garca Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee. Previous data indicated that prior carboplatin exposure is the primary risk factor for carboplatin-related hypersensitivity reactions among all patients (Navo et al., 2006; Koshiba et al., 2009). Zhonghua. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Gynecol. (2009). It didn't disappoint. Epub 2011 Jan 26. Galateanu B, Pucau AI, Tircol SA, Tanase BC, Hudita A, Negrei C, Burcea-Dragomiroiu GT, Negreanu L, Vacaroiu IA, Ginghin O. Int J Mol Sci. National Library of Medicine (2009) reported the successful re-treatment of the majority of patients with previous carboplatin-related hypersensitivity reactions.
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